Über Pterinchemie. 60. vorläufige Mitteilung [1]. Eine neue,regiospezifische Synthese von L-Biopterin

A new, regiospecific synthesis of L -biopterine Pure L -biopterine (I) is obtained in 35–40% yield by condensation of 5-desoxy-L -arabinose-hydrazone acetate with 2,4,5-triamino-6-hydroxy-pyrimidine, followed by oxidation of the formed tetrahydro-derivative and deacetylation of the L -bioterine diacetate. Catalytic reduction of the L -biopterine gives the expected mixture of two diastereomeric tetrahydro-L -biopterines.