Synthesis and antibacterial activity of new 1beta-methylcarbapenems having the potential for intramolecular nonbonded S...O interactions. |
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| Authors: | Y Nagao H Iimori K H Nam S Sano M Shiro |
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| Affiliation: | Faculty of Pharmaceutical Sciences, The University of Tokushima, Japan. ynagao@ph2.tokushima-u.ac.jp |
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| Abstract: | ![]()
Mercaptoacetyliminothiadiazoline derivatives (19, 20) useful for the pendant moiety of 1beta-methylcarbapenem antibiotics were efficiently synthesized. Acetyl derivative (18) of 20 was submitted to X-ray analysis, and a significant nonbonded S...O close contact was recognized in the crystallographic structure. New 1beta-methylcarbapenems (5, 6) were synthesized by exploiting 19 and 20, and exhibited considerable antibacterial activities in vitro. |
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