A microfluidic device for self-synchronised production of droplets |
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Authors: | Gupta Ruchi Baldock Sara J Carreras Pilar Fielden Peter R Goddard Nick J Mohr Stephan Razavi Behnam S Brown Bernard J Treves |
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Institution: | School of Electrical and Electronics Engineering, The University of Manchester, Manchester, UK. ruchi.gupta@postgrad.manchester.ac.uk |
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Abstract: | The primary requirement for a mixing operation in droplet-based microfluidic devices is an accurate pairing of droplets of reaction fluids over an extended period of time. In this paper, a novel device for self-synchronous production of droplets has been demonstrated. The device uses a change in impedance across a pair of electrodes introduced due to the passage of a pre-formed droplet to generate a second droplet at a second pair of electrodes. The device was characterised using image analysis. Droplets with a volume of ~23.5 ± 3.1 nl (i.e.~93% of the volume of pre-formed droplets) were produced on applying a voltage of 500 V. The synchronisation efficiency of the device was 83%. As the device enables self-synchronised production of droplets, it has a potential to increase the reliability and robustness of mixing operations in droplet-based microfluidic devices. |
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