Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst |
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| Authors: | Liu Tian-Yu Long Jun Li Bang-Jing Jiang Lin Li Rui Wu Yong Ding Li-Sheng Chen Ying-Chun |
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| Affiliation: | Key Laboratory of Drug-Targeting of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. |
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| Abstract: | ![]()
The bifunctional thiourea-tertiary amine derivatives of simple chiral diamines serve as highly enantioselective catalysts for the Michael addition of alpha-substituted cyanoacetates to vinyl sulfones, giving an efficient protocol for the construction of an all-carbon substituted quaternary stereocentre. |
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