pH-sensitive supramolecular copolydendrimers,new anticancer drug delivery system |
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| Authors: | Beheshteh Khodadadi Chegeni Ali Kakanejadifard Fatemeh Abedi Roya Kabiri Farkhondeh Daneshnia Mohsen Adeli |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, Iran
2. Faculty of Chemistry, Tabriz University, Tabriz, Iran
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| Abstract: | In this work, new class of supramolecular copolydendrimers (SCDs) consisting of polyamidoamines (PAMAMs) and polyglycerol were synthesized through host-guest interactions. SCDs were able to encapsulate, transport, and release doxorubicin (DOX) efficiently. Host-guest interactions between PAMAM and polyglycerol was depended on pH so that aqueous solutions of SCDs and SCDs-based drug delivery systems were stable at room temperature and pH?=?7.4, but their building blocks were separated in lower pHs( |
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