Neuroinflammation Modulation via α7 Nicotinic Acetylcholine Receptor and Its Chaperone,RIC-3 |
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| Authors: | Tehila Mizrachi Adi Vaknin-Dembinsky Talma Brenner Millet Treinin |
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| Institution: | 1.The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Hebrew University Medical School, Jerusalem 91120, Israel; (T.M.); (A.V.-D.);2.Department of Medical Neurobiology, Hadassah Medical School, Hebrew University, Jerusalem 91120, Israel |
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| Abstract: | Nicotinic acetylcholine receptors (nAChRs) are widely expressed in or on various cell types and have diverse functions. In immune cells nAChRs regulate proliferation, differentiation and cytokine release. Specifically, activation of the α7 nAChR reduces inflammation as part of the cholinergic anti-inflammatory pathway. Here we review numerous effects of α7 nAChR activation on immune cell function and differentiation. Further, we also describe evidence implicating this receptor and its chaperone RIC-3 in diseases of the central nervous system and in neuroinflammation, focusing on multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Deregulated neuroinflammation due to dysfunction of α7 nAChR provides one explanation for involvement of this receptor and of RIC-3 in neurodegenerative diseases. In this review, we also provide evidence implicating α7 nAChRs and RIC-3 in neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) involving neuroinflammation. Besides, we will describe the therapeutic implications of activating the cholinergic anti-inflammatory pathway for diseases involving neuroinflammation. |
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| Keywords: | cholinergic anti-inflammatory pathway neuroinflammation α 7 nicotinic acetylcholine receptor RIC-3 multiple sclerosis experimental autoimmune encephalomyelitis Parkinson’ s disease Alzheimer’ s disease |
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