Two new alkaloids and a new polyphenolic compound from <Emphasis Type="Italic">Cotula coronopifolia</Emphasis>

Two new alkaloid derivatives of the 3-benzazocine skeleton (cotuzine A and B) and a new polyphenolic substance (3-(1,3-dihydroxyprop-2-yl)-4-hydroxyanisol) (corimen) have been isolated from the aerial part (stems, leaves) of the plant Cotula coronopifolia (L.). These three new structures were established by spectroscopic procedures (¹H, ¹³C, one- and two-dimensional NMR). The stereochemistry of the new alkaloids was established based on different NOE effects revealed on the NOESY spectrum. Mass spectrometry and IR spectroscopy were used to confirm these structures.