A diagnostic tool for determining the quality of accuracy validation. Assessing the method for determination of nitrate in drinking water |
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Authors: | L Escuder-Gilabert E Bonet-Domingo M J Medina-Hernández S Sagrado |
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Institution: | (1) General de Análisis Materiales y Servicios (GAMASER) S.L., 46014 Valencia, Spain;(2) Departamento de Química Analítica, Universitat de València, C/Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain |
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Abstract: | Realistic internal validation of a method implies the performance validation experiments under intermediate precision conditions.
The validation results can be organized in an X
Nr×Ns
(replicates×runs) data matrix, analysis of which enables assessment of the accuracy of the method. By means of Monte Carlo
simulation, uncertainty in the estimates of bias and precision can be assessed. A bivariate plot is presented for assessing
whether the uncertainty intervals for the bias (E ± U(E)) and intermediate precision (RSDi ± U(RSDi) are included in prefixed limits (requirements for the method). As a case study, a method for determining the concentration
of nitrate in drinking water at the official level set by 98/83/EC Directive is assessed by use of the proposed plot. |
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Keywords: | Accuracy validation Intermediate precision Uncertainty estimation Monte Carlo simulation |
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