| 2-苯基-1-(4-(1-吡咯乙氧基)苯基)乙酮的合成 |
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| 引用本文： | 李高伟,王晓娟,赵文献,郭保国.2-苯基-1-(4-(1-吡咯乙氧基)苯基)乙酮的合成[J].化学研究与应用,2012,24(6):936-939. |
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| 作者姓名： | 李高伟 王晓娟 赵文献 郭保国 |
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| 作者单位： | 商丘师范学院化学化工学院有机新材料合成重点实验室,河南商丘,476000 |
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| 基金项目： | 国家自然科学基金，河南省教育厅自然科学研究计划项目 |
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| 摘 要： | 2-苯基-1-(4-(1-吡咯乙氧基)苯基)乙酮是合成抗骨质疏松药拉索昔芬重要的结构片段。以苯酚为原料经成醚,磺酰氯酯化得到磺酸酯,然后经亲核取代反应,傅-克酰基化反应高收率地合成了目标化合物,其结构通过NMR和HRMS进行了表征。
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| 关 键 词： | 拉索昔芬 2-苯基-1-(4-(1-吡咯乙氧基)苯基)乙酮 合成 |
Synthesis of 2-Phenyl(4-pyrrolidinylethoxyphenyl) ethan-1 -one |
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| LI Gao-wei
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WANG Xiao-juan
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ZHAO Wen-xian
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GUO Bao-guo.Synthesis of 2-Phenyl(4-pyrrolidinylethoxyphenyl) ethan-1 -one[J].Chemical Research and Application,2012,24(6):936-939. |
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| Authors: | LI Gao-wei WANG Xiao-juan ZHAO Wen-xian GUO Bao-guo |
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| Institution: | (Key Laboratory of New Organic Materials Synthesis,School of Chemistry and Chemical Engineering,Shangqiu Normal University,Shangqiu 476000,China) |
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| Abstract: | 2-phenyl(4-pyrrolidinylethoxyphenyl)ethan-1-one was important structural fragments of antiosteoporosis drug Lasofoxifene.The intermediate was prepared by etherification,esterification with tosyl chloride in a simple and efficient step from phenol,and then the title compound was obtained by nucleophilic substitution and Friedel-Crafts acylation reaction in high yield.The chemical structure of the compound was characterized by NMR and HRMS. |
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| Keywords: | lasofoxifene 2-phenyl(4-pyrrolidinylethoxyphenyl)ethan-1-one synthesis |
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