Recent Advances in the Semisynthesis,Modifications and Biological Activities of Ocotillol-Type Triterpenoids |
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| Authors: | Yucheng Cao Kaiyi Wang Si Xu Lingtan Kong Yi Bi Xiaopeng Li |
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| Institution: | School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China; (Y.C.); (K.W.); (S.X.); (L.K.); (X.L.) |
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| Abstract: | Ginseng is one of the most widely consumed herbs in the world and plays an important role in counteracting fatigue and alleviating stress. The main active substances of ginseng are its ginsenosides. Ocotillol-type triterpenoid is a remarkably effective ginsenoside from Vietnamese ginseng that has received attention because of its potential antibacterial, anticancer and anti-inflammatory properties, among others. The semisynthesis, modification and biological activities of ocotillol-type compounds have been extensively studied in recent years. The aim of this review is to summarize semisynthesis, modification and pharmacological activities of ocotillol-type compounds. The structure–activity relationship studies of these compounds were reported. This summary should prove useful information for drug exploration of ocotillol-type derivatives. |
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| Keywords: | biological activity modification semisynthetic ocotillol-type triterpenoids |
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