Rational Design of [13C,D14]Tert‐butylbenzene as a Scaffold Structure for Designing Long‐lived Hyperpolarized 13C Probes |
| |
Authors: | Yuki Imakura Dr Hiroshi Nonaka Dr Yoichi Takakusagi Prof?Dr Kazuhiro Ichikawa Nesmine R Maptue Dr Alexander M Funk Prof?Dr Chalermchai Khemtong Prof?Dr Shinsuke Sando |
| |
Institution: | 1. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;2. Incubation Center for Advanced Medical Science, Kyushu University, Higashi-ku, Fukuoka, Japan;3. Innovation Center for Medical Redox Navigation, Kyushu University, Higashi-ku, Fukuoka, Japan;4. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA;5. Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA |
| |
Abstract: | Dynamic nuclear polarization (DNP) is a technique to polarize the nuclear spin population. As a result of the hyperpolarization, the NMR sensitivity of the nuclei in molecules can be dramatically enhanced. Recent application of the hyperpolarization technique has led to advances in biochemical and molecular studies. A major problem is the short lifetime of the polarized nuclear spin state. Generally, in solution, the polarized nuclear spin state decays to a thermal spin equilibrium, resulting in loss of the enhanced NMR signal. This decay is correlated directly with the spin‐lattice relaxation time T1. Here we report 13C,D14]tert‐butylbenzene as a new scaffold structure for designing hyperpolarized 13C probes. Thanks to the minimized spin‐lattice relaxation (T1) pathways, its water‐soluble derivative showed a remarkably long 13C T1 value and long retention of the hyperpolarized spin state. |
| |
Keywords: | chemical probe dynamic nuclear polarization hyperpolarization nuclear magnetic resonance spin-lattice relaxation time |
|
|