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| 用手性配体改性铝锂试剂对芳香酮的还原 | |
| 引用本文： | 董淑荣 尹承烈. 用手性配体改性铝锂试剂对芳香酮的还原[J]. 合成化学, 1999, 7(3): 226-228 |
| 作者姓名： | 董淑荣 尹承烈 |
| 作者单位： | 北京师范大学化学系!北京，100875，北京师范大学化学系!北京，100875 |
| 基金项目： | 国家自然科学基金，国家教委博士点基金 |
| 摘 要： | 用手性一元酮作辅助配体，与１，２，５，６－二丙酮甘ｉＡｌｈ５对芳香酮进行对映选择 的，得到光学活性产物８个。通过与α－乙酰氧基－Ｌ－丙酰氯生成非对映异构体酯，经气相色谱分析，芳酮挑学产率为２３．３￣７１．２％。初步探讨了配体之间对称性匹配的情况。 |
| 关 键 词： | 还原 改性 铝锂试剂 手性醇 不对称还原 芳香酮 |
Asymmetric Reduction of Aliphatic Ketone by 1,2,5,6 Diisopropylidenemannitol Modified Lithium Aluminum Hydride Reagents |
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| Dong,Su Rong Yin,Cheng Lie. Asymmetric Reduction of Aliphatic Ketone by 1,2,5,6 Diisopropylidenemannitol Modified Lithium Aluminum Hydride Reagents[J]. Chinese Journal of Synthetic Chemistry, 1999, 7(3): 226-228 | |
| Authors: | Dong Su Rong Yin Cheng Lie |
| Abstract: | Lithium aluminum hydride modified with 1,2,5,6 diisopropylidenemannitol and other chiral alcohols was applied to reduce aromatic ketones to yield the corresponding optically active alcohols which were converted to their diastereoisomers with actyl L propionyl chloride. Gas chromatography quantitative analysis showed that the opticalyields of asymmetric reduction of aromatic ketone fell between 23.3% ~71.2%. The effect of the symmetrical matchness of ligands had also been studied. |
| Keywords: | Modification Chiral alcohol Asymmetric reduction Diastereoisomer. |
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