| Preliminary Screening of Non-platinum Complexes of Schiff Bases as Antitumour Agents Using Fluorimetry |
| |
| 引用本文： | 李志良,陈建华,章开诚,李梦龙,俞汝勤. Preliminary Screening of Non-platinum Complexes of Schiff Bases as Antitumour Agents Using Fluorimetry[J]. 中国科学B辑(英文版), 1993, 0(2) |
| |
| 作者姓名： | 李志良 陈建华 章开诚 李梦龙 俞汝勤 |
| |
| 作者单位： | Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410082，PRC，Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410082，PRC，Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410082，PRC，Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410082，PRC，Department of Chemistry and Chemical Engineering，Hunan University，Changsha 410082，PRC |
| |
| 基金项目： | Project supported by the State Education Commission Foundation，the National Natural Science Foundation of China. |
| |
| 摘 要： | ![]()
Based on the consistency of the in vivo and in vitro interactions of drugs with DNA, a fluorimetric method has been developed as a new in vitro method for preliminary screening of antitumour agents. This method was tested using Schiff bases synthesized from salicylaldehyde with 1-alanine, 1-asparagine and 1-histidine, and complexes of these Schiff bases with Cu(Ⅱ), Zn(Ⅱ), Ni(Ⅱ) and Sn(Ⅳ) as potential antitumour agents.The study of the interaction of the complexes with DNA by a fluorescence probe ethidium bromide (EthBr)-DNA system indicated the parallelism between the binding constants and antineoplastic ratios. The relationship between structure and antitumonr activity was investigated.
|
Preliminary Screening of Non-platinum Complexes of Schiff Bases as Antitumour Agents Using Fluorimetry |
| |
| LI Zhi-Liang CHEN Jian-Hua ZHANG Kai-Cheng LI Meng-Long YU Ru-Qin. Preliminary Screening of Non-platinum Complexes of Schiff Bases as Antitumour Agents Using Fluorimetry[J]. Science in China(Chemistry), 1993, 0(2) |
| |
| Authors: | LI Zhi-Liang CHEN Jian-Hua ZHANG Kai-Cheng LI Meng-Long YU Ru-Qin |
| |
| Abstract: | ![]()
|
| |
| Keywords: | fluoreseenee probe in vitro screening of antitumour drugs non-platinum complex of Schiff base. |
| 本文献已被 CNKI 等数据库收录！ |
