| Enantioseparation of Novel Chiral Tetrahedral Clusters on an Amylosoe Tris-（3,5-dimethylphenylcarbamate） Chiral Stationary Phase by Normal Phase HPLC |
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| 引用本文： | 李文智,王霞,张伟强,陈立仁,李永民,马春林,殷元骐.Enantioseparation of Novel Chiral Tetrahedral Clusters on an Amylosoe Tris-（3,5-dimethylphenylcarbamate） Chiral Stationary Phase by Normal Phase HPLC[J].中国化学,2004,22(10):1070-1074. |
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| 作者姓名： | 李文智 王霞 张伟强 陈立仁 李永民 马春林 殷元骐 |
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| 作者单位： | [1]LanzhouInstituteofChemicalPhysics,ChineseAcademyofSciences,Lanzhou,Gansu730000,China [2]DepartmentofChemistry,LiaochengUniversity,Liaocheng,Shandong252059,China |
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| 摘 要： | Amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) coated on a kind of small particle silica gel was prepared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transition metal tetrahedral clusters has firstly been achieved using n-hexane as the mobile phase containing various alcohols as modifiers. The effect of mobile phase modifiers and the structural variation of the solutes on their retention factors (k‘) and resolutions (Rs) were investigated. The result suggests that not only the structure and concentration of alcohol in mobile phase, but also the structural differences in racemates can have a pronounced effect on enantiomeric separation. ADMPC-CSP is a suitable CSP for the optical resolution of chiral tetrahedral cluster by HPLC.
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| 关 键 词： | 手性分离 直链淀粉三-（3 5-二甲基苯基氨基甲酸盐） 手性固定相 高效液相色谱 手性四面体簇 |
Enantioseparation of novel chiral tetrahedral clusters on an amylose tris‐(3,5‐dimethylphenylcarbamate) chiral stationary phase by normal phase HPLC |
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| Wen‐Zhi Li,Xia Wang,Wei‐Qiang Zhang,Chen Li‐Ren,Yong‐Min Li,Chun‐Lin Ma,Yuan‐Qi Yin.Enantioseparation of novel chiral tetrahedral clusters on an amylose tris‐(3,5‐dimethylphenylcarbamate) chiral stationary phase by normal phase HPLC[J].Chinese Journal of Chemistry,2004,22(10):1070-1074. |
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| Authors: | Wen‐Zhi Li Xia Wang Wei‐Qiang Zhang Chen Li‐Ren Yong‐Min Li Chun‐Lin Ma Yuan‐Qi Yin |
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| Abstract: | Amylose tris(3,5‐dimethylphenylcamate) (ADMPC) coated on a kind of small particle silica gel was prepared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transition metal tetrahedral clusters has firstly been achieved using n‐hexane as the mobile phase containing various alcohols as modifiers. The effect of mobile phase modifiers and the structural variation of the solutes on their retention factors (k) and resolutions (Rs) were investigated. The result suggests that not only the structure and concentration of alcohol in mobile phase, but also the structural differences in racemates can have a pronounced effect on enantiomeric separation. ADMPC‐CSP is a suitable CSP for the optical resolution of chiral tetrahedral cluster by HPLC. |
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| Keywords: | enantiomeric separation HPLC chiral stationary phase amylose tris(3 5‐dimethylphenylcarbamate) chiral tetrahedral cluster |
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