| Formation, Structure and In Vitro Antitumour Activity of a Novel Binuclear Organotin Complex |
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| 作者姓名： | Lai Jin TIAN Yu Xi SUN Guo Ming YANG Bo Chu QIAN Zhi Cai SHANG |
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| 作者单位： | [1]Department of Chemistry, Qufu Normal University, Qufu 273165 [2]Department of Chemistry, Zhejiang University, Hangzhou 310027 [3]Institute of Materia Medica, Zhejiang Academy of Medical Science, Hangzhou 310013 |
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| 摘 要： | A 1：1 reaction of triphenyltin chloride with potassium N-（3,5-dibromo-2-hydroxylphenyl）methylene]valinate in benzene led to the formation of a novel mixed organotin dinuclear complex, （HL）SnPh3oPh2SnL L=2-O-3,5-Br2C6H3CH=NCH（i-Pr）COO], by means of a facile phenyl-tin bond cleavage process. In the complex, there are two distinct types of carboxylate moieties and a trans-O2SnC2N and a trans-O2SnC3 in distorted trigonal bipyramidal geometries were bridged by a carboxylate group. In vitro antitumor activity of the complex against three human tumour cell lines （HeLa, CoLo205 and MCF-7） was found to be much higher than cis-platin used in clinic.
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| 关 键 词： | 锡 羧酸酯 合成方法 晶体结构 化合物 |
| 收稿时间： | 2005-04-01 |
Formation, Structure and In Vitro Antitumour Activity of a Novel Binuclear Organotin Complex |
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| Lai Jin TIAN Yu Xi SUN Guo Ming YANG Bo Chu QIAN Zhi Cai SHANG.Formation, Structure and In Vitro Antitumour Activity of a Novel Binuclear Organotin Complex[J].Chinese Chemical Letters,2005,16(12):1584-1586. |
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| Authors: | Lai Jin TIAN Yu Xi SUN Guo Ming YANG Bo Chu QIAN Zhi Cai SHANG |
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| Abstract: | A 1:1 reaction of triphenyltin chloride with potassium N-(3,5-dibromo-2-hydroxyl- phenyl)methylene]valinate in benzene led to the formation of a novel mixed organotin dinuclear complex, (HL)SnPh3Ph2SnL L=2-O-3,5-Br2C6H3CH=NCH(i-Pr)COO], by means of a facile phenyl-tin bond cleavage process. In the complex, there are two distinct types of carboxylate moieties and a trans-O2SnC2N and a trans-O2SnC3 in distorted trigonal bipyramidal geometries were bridged by a carboxylate group. In vitro antitumor activity of the complex against three human tumour cell lines (HeLa, CoLo205 and MCF-7) was found to be much higher than cis-platin used in clinic. |
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| Keywords: | Binuclear tin complex organotin carboxylate antitumor activity crystal structure |
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