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Cyanamides in cyclization reactions with anthranilates, 2-aminophenyl ketones, and methyl 2-(3-oxopiperazin-2-yl)acetate
Authors:Kh. S. Shikhaliev  A. S. Shestakov  S. M. Medvedeva  N. V. Gusakova
Affiliation:(1) Voronezh State University, 1 Universitetskaya pl., 394006 Voronezh, Russian Federation
Abstract:Cyclization of aryl-, aroyl-, and (4,6-dimethylpyrimidin-2-yl)cyanamides with methyl anthranilates, 2-aminophenyl ketones, and methyl 2-(3-oxopiperazin-2-yl)acetate leads to 2-amino-3,4-dihydroquinazolin-4-one, 2-aminoquinazoline, and 6-amino-1,3,4,8,9,9a-hexahydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione derivatives, respectively. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 164–170, January, 2008.
Keywords:cyanamides  anthranilic acid  2-aminophenyl ketones  methyl 2-(3-oxopiperazin-2-yl)acetate  2-aminoquinazoline  2-amino-3,4-dihydroquinazolin-4-one  6-amino-1,3,4,8,9,9a-hexahydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione  cyclization
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