Cyanamides in cyclization reactions with anthranilates, 2-aminophenyl ketones, and methyl 2-(3-oxopiperazin-2-yl)acetate |
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Authors: | Kh. S. Shikhaliev A. S. Shestakov S. M. Medvedeva N. V. Gusakova |
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Affiliation: | (1) Voronezh State University, 1 Universitetskaya pl., 394006 Voronezh, Russian Federation |
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Abstract: | Cyclization of aryl-, aroyl-, and (4,6-dimethylpyrimidin-2-yl)cyanamides with methyl anthranilates, 2-aminophenyl ketones, and methyl 2-(3-oxopiperazin-2-yl)acetate leads to 2-amino-3,4-dihydroquinazolin-4-one, 2-aminoquinazoline, and 6-amino-1,3,4,8,9,9a-hexahydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione derivatives, respectively. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 164–170, January, 2008. |
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Keywords: | cyanamides anthranilic acid 2-aminophenyl ketones methyl 2-(3-oxopiperazin-2-yl)acetate 2-aminoquinazoline 2-amino-3,4-dihydroquinazolin-4-one 6-amino-1,3,4,8,9,9a-hexahydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione cyclization |
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