Poly(vinyl alcohol)-Graft-Poly(ethylene glycol)-Supported Hydroxyproline Catalysis of Stereoselective Aldol Reactions |
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Authors: | Tarek Kassem Xin Jia XX Zhu William D Lubell |
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Institution: | Département de Chimie, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC, H3C 3J7, Canada |
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Abstract: | Summary: The good swelling and high loading of poly(vinyl alcohol)-graft-poly(ethylene glycol) (PVA-g-PEG) resins proved to be effective for performing supported proline-catalyzed aldol reactions stereoselectively in a wide range of polar non-protic, protic and non-polar solvents as well as in neat substrate. The catalysts could be recovered by filtration and recycled, without significant loss of activity. The use of poly(vinyl alcohol)-graft-poly(ethylene glycol) matrix improved the solubility of the proline-derived catalysts and expanded the scope of permissible solvents for performing selective aldol chemistry. |
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Keywords: | catalysis enantioselective synthesis green chemistry poly(vinyl alcohol)-graft-poly(ethylene glycol) polymer supports |
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