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Designer Self-Assembling Peptide Materials for Diverse Applications
Authors:Charlotte A.E. Hauser  Shuguang Zhang
Affiliation:Institute of Bioengineering and Nanotechnology, A*STAR, 31 Biopolis Way, The NANOS, 138669 Singapore
Abstract:Summary: Macromolecuar chemistry and polymer science have had an enormous impact in many areas of science, engineering, medicine and our daily life. It has not only changed our way of life forever, but also continuously to improve our living standard. Macromolecuar chemistry now also encompasses bioengineering, biomimetics, designer biological materials and nanobiotechnology. Here we summarize a few classes of short peptides that we discovered and invented with broad applications including 3D tissue cell culture, reparative and regenerative medicine, tissue engineering, slow drug release, stabilization of membrane proteins for develop nanobiotechnology and molecular devices. Molecular design using short peptides as new materials will play increasingly important role in biomedical research, nanobiotechnology, clinical science and medicine.
Keywords:3D cell cultures  ionic self-complementary peptides  lipid-like peptides  molecular self-assembly  stabilizing membrane proteins  tissue regeneration
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