Biogenic Polyelectrolyte Multilayers on Poly(L-lactide) Films for Control of Osteoblast Adhesion |
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| Authors: | Zhen-Mei Liu Qin-Yi Gu Aminatou Barry Zhi-Kang Xu Thomas Groth |
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| Institution: | 1. Biomedical Materials Group, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Heinrich-Damerow-Strasse 4, 06120 Halle (Saale), Germany;2. Institute of Polymer Science, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China |
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| Abstract: | Cell adhesion and spreading are important events during cell-biomaterial interaction, which control survival, growth and differentiation of cells. Layer-by-layer technique was used to generate multilayer coatings for regulating adhesion of primary osteoblasts on biomaterials. Polyelectrolyte multilayers (PEM) were based on poly (ethylene imine) as primary polycation layer. PEM were then prepared from chitosan (CHI) as polycation and heparin (HEP), or sulfated HA (sHA) as polyanions. It was observed that attachment and spreading of primary osteoblasts (pOB) was highly dependent on the composition of multilayers, as well as pH values of polyelectrolyte solutions. Results presented in this paper may pave the way for application of PEM surface coatings for bone-contacting implant materials. |
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| Keywords: | biocompatibility layer-by-layer assembly poly(L-lactide) polyelectrolytes primary osteoblasts |
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