Enantioseparation of glutethimide and its 5-OH-metabolite in capillary electrophoresis and study of selector-selectand interactions using one-dimensional rotating frame nuclear Overhauser and exchange spectroscopy |
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| Authors: | Chankvetadze Bezhan Burjanadze Naira Bergander Klaus Blaschke Gottfried |
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| Institution: | Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany. chankve@uni-muenster.de |
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| Abstract: | Enantioseparation of glutethimide (GT) and its 5-hydroxy metabolite (5-OH-GT) has been studied with several charged cyclodextrin (CD) derivatives. The emphasis was made on the enantiomer migration order of GT and simultaneous enantioseparation of GT and 5-OH-GT. The possible structural differences of GT complexes with three different single isomer charged CD derivatives were studied using one-dimensional rotating frame nuclear Overhauser and exchange spectroscopy (1-D ROESY). |
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