Probing the Limits of Selectivity in a Recognition‐Mediated Reaction Network Embedded within a Dynamic Covalent Library |
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| Authors: | Tamara Kosikova Harry Mackenzie Prof. Douglas Philp |
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| Affiliation: | 1. School of Chemistry and EaStCHEM, University of St. Andrews, North Haugh, St. Andrews, UK;2. UCB, Slough, Berks, UK |
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| Abstract: | Two recognition‐mediated reaction processes operating through reactive binary complexes drive resolution of a 24‐component dynamic covalent library, assembled from individual aldehydes and nucleophiles. The effectiveness of the library resolution and selective amplification of one recognition‐enabled species over another is limited by the difference in the rates of the recognition‐mediated reactive processes and the strength of the recognition processes employed in the dynamic system. |
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| Keywords: | combinatorial chemistry cycloaddition reaction kinetics molecular recognition NMR spectroscopy |
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