tert‐Butyl Iodide Mediated Reductive Fischer Indolization of Conjugated Hydrazones |
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| Authors: | Yuta Ito Dr. Masafumi Ueda Dr. Norihiko Takeda Prof. Dr. Okiko Miyata |
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| Affiliation: | 1. Kobe Pharmaceutical University, Higashinada, Kobe, Japan;2. (+81)?78‐441‐7554 |
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| Abstract: | A novel reductive Fischer indolization of readily available N‐aryl conjugated hydrazones with tert‐butyl iodide has been developed. In this reaction, tert‐butyl iodide is used as anhydrous HI source, and the generated HI acts as a Brønsted acid and a reducing agent. This operationally simple method allows access to various indole derivatives. Furthermore, the procedure can be applied to the synthesis of biologically active compounds. |
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| Keywords: | hydrazones indoles iodine reduction sigmatropic rearrangement |
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