| Design,synthesis,characterization,cytotoxic and structure activity relationships of novel Ru(Ⅱ) complexes |
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| 引用本文： | Sreekanth Thota,Srujana Vallala,Rajeshwar Yerra,Eliezer J. Barreiro. Design,synthesis,characterization,cytotoxic and structure activity relationships of novel Ru(Ⅱ) complexes[J]. 中国化学快报, 2015, 26(6): 721-726. DOI: 10.1016/j.cclet.2015.03.011 |
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| 作者姓名： | Sreekanth Thota Srujana Vallala Rajeshwar Yerra Eliezer J. Barreiro |
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| 基金项目： | This work was supported by National Council for Scientific and Technological Development (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Oswaldo Cruz Foundation (Fiocruz) and Department of Science and Technology, New Delhi, India [No. SR/WOS-A/LS-562/2011) dated 27/03/2012]. |
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| 收稿时间： | 2014-12-12 |
| 修稿时间： | 2015-02-27 |
Design,synthesis, characterization,cytotoxic and structure activity relationships of novel Ru(II) complexes |
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| Sreekanth Thota,Srujana Vallala,Rajeshwar Yerra,Eliezer J. Barreiro. Design,synthesis, characterization,cytotoxic and structure activity relationships of novel Ru(II) complexes[J]. Chinese Chemical Letters, 2015, 26(6): 721-726. DOI: 10.1016/j.cclet.2015.03.011 |
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| Authors: | Sreekanth Thota Srujana Vallala Rajeshwar Yerra Eliezer J. Barreiro |
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| Abstract: | Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by high toxicity. Ruthenium containing complexes have long been known to be well suited for biological applications, and have long been utilized as replacements to popular platinum based-drugs. Here, we report a novel series of ruthenium(II) arene compounds bearing thiosemicarbazone and isonicotinylhydrazone ligands with potent anticancer activity their structure activity relationships and apoptosis was studied. The cytotoxic activity of the new ruthenium(II) arene compounds has been evaluated in several cell lines (Molt 4/C8, L1210, CEM, HL60 and BEL7402). Among them, ten complexes were found to be excellent in vitro growth inhibitory activity against various cell lines with IC50 in the sub-micromolar range. |
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| Keywords: | Cytotoxic Ligand Ruthenium compounds Structure activity relationships |
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