Highly enantioselective catalytic acyl-pictet-spengler reactions |
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| Authors: | Taylor Mark S Jacobsen Eric N |
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| Institution: | Harvard University, Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. |
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| Abstract: | The enantioselective cyclization of N-acyliminium ions generated in situ from tryptamine is promoted with high enantioselectivity by a new chiral thiourea catalyst. This represents the first successful system for asymmetric catalysis of the Pictet-Spengler reaction. |
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