Continuous flow metal-free oxidation of picolines using air |
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| Authors: | Hamano Masaya Nagy Kevin D Jensen Klavs F |
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| Affiliation: | Chemical Process Research Laboratories, Fukui Research Institute, Ono Pharmaceutical Co., Ltd., 50-10 Yamagishi, Mikuni, Sakai, Fukui 913-0032, Japan. |
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| Abstract: | ![]()
The metal free, direct oxidation of 2-, 3-, and 4-picoline to the corresponding carboxylic acid using either oxygen or air has been developed under continuous flow conditions. Complete conversion for all three substrates was obtained at moderate temperatures and pressures within minutes. |
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