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Phenyltrimethylammonium Salts as Methylation Reagents in the Nickel‐Catalyzed Methylation of C−H Bonds
Authors:Takeshi Uemura  Mao Yamaguchi  Prof. Dr. Naoto Chatani
Affiliation:Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka, Japan
Abstract:Methylation of C(sp2)?H bonds was achieved through the NiII‐catalyzed reaction of benzamides with phenyltrimethylammonium bromide or iodide as the source of the methyl group. The reaction has a broad scope and shows high functional‐group compatibility. The reaction is also applicable to the methylation of C(sp3)?H bonds in aliphatic amides.
Keywords:C−  H activation  chelation assistance  methylation  nickel  phenyltrimethylammonium iodide
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