Silver‐Mediated Intermolecular 1,2‐Alkylarylation of Styrenes with α‐Carbonyl Alkyl Bromides and Indoles |
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| Authors: | Xuan‐Hui Ouyang Dr Ren‐Jie Song Ming Hu Yuan Yang Prof?Dr Jin‐Heng Li |
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| Institution: | 1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China;2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China |
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| Abstract: | A new iron‐facilitated silver‐mediated radical 1,2‐alkylarylation of styrenes with α‐carbonyl alkyl bromides and indoles is described, and two new C?C bonds were generated in a single step through a sequence of intermolecular C(sp3)?Br functionalization and C(sp2)?H functionalization across the alkenes. This method provides an efficient access to alkylated indoles with broad substrate scope and excellent selectivity. |
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| Keywords: | alkenes C− H functionalization heterocycles iron silver |
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