|
|||||
|
|
Multifunctional Antioxidants: Regenerable Radical‐Trapping and Hydroperoxide‐Decomposing Ebselenols |
|
| Authors: | Shailesh Kumar Jiajie Yan Jia‐fei Poon Dr. Vijay P. Singh Dr. Xi Lu Dr. Marjam Karlsson Ott Prof. Dr. Lars Engman Prof. Dr. Sangit Kumar |
| Affiliation: | 1. Department of Chemistry, Indian Institute of Science Education and Research (IISER), Bhopal-, India;2. Department of Chemistry—BMC, Uppsala University, Uppsala, Sweden;3. Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, Sweden |
| Abstract: | Regenerable, multifunctional ebselenol antioxidants were prepared that could quench peroxyl radicals more efficiently than α‐tocopherol. These compounds act as better mimics of the glutathione peroxidase enzymes than ebselen. Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human mononuclear cells was considerably decreased upon exposure to the organoselenium compounds. At a concentration of 25 μm , the ebselenol derivatives showed minimal toxicity in pre‐osteoblast MC3T3 cells. |
| Keywords: | antioxidants ascorbic acid ebselen selenium cytotoxicity |