Bottom‐Up Fabrication of Nanopatterned Polymers on DNA Origami by In Situ Atom‐Transfer Radical Polymerization |
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| Authors: | Yu Tokura Yanyan Jiang Dr Alexander Welle Prof Martina H Stenzel Katarzyna M Krzemien Prof Jens Michaelis Dr Rüdiger Berger Prof Christopher Barner‐Kowollik Dr Yuzhou Wu Prof Tanja Weil |
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| Institution: | 1. Organic Chemistry III, Macromolecular Chemistry and Biomaterials, Ulm University, Ulm, Germany;2. Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW, Australia;3. Preparative Macromolecular Chemistry, Institute for Technical Chemistry and Polymer Chemistry, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany;4. Institute for Biological Interfaces, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany;5. Karlsruhe Nano Micro Facility, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany;6. Institute of Biophysics, Ulm University, Ulm, Germany;7. Max Planck Institute for Polymer Research, Mainz, Germany |
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| Abstract: | Bottom‐up strategies to fabricate patterned polymers at the nanoscale represent an emerging field in the development of advanced nanodevices, such as biosensors, nanofluidics, and nanophotonics. DNA origami techniques provide access to distinct architectures of various sizes and shapes and present manifold opportunities for functionalization at the nanoscale with the highest precision. Herein, we conduct in situ atom‐transfer radical polymerization (ATRP) on DNA origami, yielding differently nanopatterned polymers of various heights. After cross‐linking, the grafted polymeric nanostructures can even stably exist in solution without the DNA origami template. This straightforward approach allows for the fabrication of patterned polymers with low nanometer resolution, which provides access to unique DNA‐based functional hybrid materials. |
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| Keywords: | atom-transfer radical polymerization DNA nanotechnology origami nanostructures polymerization self-assembly |
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