Oxidative Conversion of a Europium(II)‐Based T1 Agent into a Europium(III)‐Based paraCEST Agent that can be Detected In Vivo by Magnetic Resonance Imaging |
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| Authors: | Dr Alexander M Funk Dr Veronica Clavijo?Jordan Prof A Dean Sherry Dr S James Ratnakar Prof Zoltan Kovacs |
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| Institution: | 1. Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA;2. Department of Chemistry, University of Texas, Dallas, Richardson, TX, USA |
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| Abstract: | The EuII complex of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most EuII chelates reported to date. The reduced EuII form acts as an efficient water proton T1 relaxation reagent, while the EuIII form acts as a water‐based chemical exchange saturation transfer (CEST) agent. The complex has extremely fast water exchange rate. Oxidation to the corresponding EuIII complex yields a well‐defined signal from the paraCEST agent. The time course of oxidation was studied in vitro and in vivo by T1‐weighted and CEST imaging. |
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| Keywords: | contrast agents divalent lanthanides europium paraCEST T1 weighting |
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