Enantiocontrolled synthesis of alpha-methyl amino acids via Bn2N-alpha-methylserine-beta-lactone |
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| Authors: | Smith Nicole D Wohlrab Aaron M Goodman Murray |
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| Affiliation: | Department of Chemistry, University of California, San Diego, La Jolla, California 92093, USA. smithn@uchicago.edu |
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| Abstract: | [Reaction: see text] Enantiocontrolled synthesis of alpha-methyl amino acids proceeds via the regioselective organocuprate opening of Bn2N-alpha-methylserine-beta-lactone. From this chiral intermediate, a wide variety of alpha-methyl amino acids and building blocks were synthesized in excellent yields. |
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