A Paclitaxel Prodrug Activatable by Irradiation in a Hypoxic Microenvironment |
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| Authors: | Dr Shiyu Zhou Prof Xiuli Hu Dr Rui Xia Shi Liu Qing Pei Prof Guang Chen Prof Zhigang Xie Prof Xiabin Jing |
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| Institution: | 1. Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin, 130021 China;2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 China |
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| Abstract: | The innate hypoxic microenvironment of most solid tumors has a major influence on tumor growth, invasiveness, and distant metastasis. Here, a hypoxia-activated self-immolative prodrug of paclitaxel (PTX2-Azo) was synthesized and encapsulated by a peptide copolymer decorated with the photosensitizer chlorin e6 (Ce6) to prepare light-boosted PTX nanoparticle (Ce6/PTX2-Azo NP). In this nanoparticle, PTX2-Azo prevents premature drug leakage and realizes specific release in hypoxic tumor microenvironment and the photosensitizer Ce6 not only efficiently generates singlet oxygen under light irradiation but also acts as a positive amplifier to promote the release of PTX. The combination of photodynamic therapy (PDT) and chemotherapy results in excellent antitumor efficacy, demonstrating the great potential for synergistic cancer therapy. |
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| Keywords: | combination therapy hypoxia paclitaxel photodynamic therapy prodrugs |
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