Pd(0)-guanidine@MCM-41: a very effective catalyst for rapid production of bis (pyrazolyl)methanes |
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| Authors: | Hossein Filian Alireza Kohzadian Masoud Mohammadi Arash Ghorbani-Choghamarani Amirali Karami |
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| Institution: | 1. Department of Chemistry, Khuzestan Science and Research Branch, Islamic Azad University, Ahvaz, Iran;2. Young Researchers Club, Ilam Branch, Islamic Azad University, Ilam, Iran;3. Department of Chemistry, Faculty of Science, Ilam University, P. O. Box 69315516 Ilam, Iran |
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| Abstract: | In this research, a rapid, green and efficient protocol for synthesis of bis (pyrazolyl)methane derivatives in the presence of Pd(0)-guanidine@MCM-41 catalysts under solvent-free conditions by the following two methods has been reported: (i) via the one-pot pseudo five-component reaction among phenylhydrazine (2 equivalents), ethyl acetoacetate (2 equivalents) and aromatic aldehydes (1 equivalent); and (ii) the one-pot pseudo three-component reaction between 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (2 equivalents) and aromatic aldehydes (1 equivalent). Some advantages of this protocol include: green conditions, extremely short times, high efficiency, proper one-pot operation, generality of method, easy work-up and recyclability, and reusability of the catalyst up to five times without significant loss in catalytic activity. |
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| Keywords: | bis (pyrazolyl)methanes heterogeneous catalyst multi-component reaction Pd(0)-guanidine@MCM-41 reusable catalyst |
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