Water-Soluble Non-Classical Benzene Mimetics |
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| Authors: | Vadym V Levterov Dr Yaroslav Panasyuk Valentyna O Pivnytska Dr Pavel K Mykhailiuk |
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| Institution: | 1. Enamine Ltd., Chervonotkatska 78, 02094 Kyiv, Ukraine;2. Bienta, Chervonotkatska 78, Kyiv, 02094 Ukraine |
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| Abstract: | A new generation of saturated benzene mimetics, 2-oxabicyclo2.1.1]hexanes, was developed. These compounds were designed as analogues of bicyclo1.1.1]pentane with an improved water solubility. Crystallographic analysis of 2-oxabicyclo2.1.1]hexanes revealed that they occupy a novel chemical space, but, at the same time, resemble the motif of meta-disubstituted benzenes. |
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| Keywords: | BCP Benzolmimetika Bicyclo[1 1 1]pentan Bioisostere Wasserlöslichkeit |
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