Tumor Microenvironment-Activated NIR-II Nanotheranostic System for Precise Diagnosis and Treatment of Peritoneal Metastasis |
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| Authors: | Sisi Ling Xiaohu Yang Dr Chunyan Li Yejun Zhang Dr Hongchao Yang Dr Guangcun Chen Prof Qiangbin Wang |
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| Institution: | 1. School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China
CAS Key Laboratory of Nano-Bio Interface, Suzhou Key Laboratory of Functional Molecular Imaging Technology, Division of Nanobiomedicine andi-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China;2. School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China |
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| Abstract: | Activatable theranostic systems show potential for improved tumor diagnosis and therapy owing to high detection specificities, effective ablation, and minimal side-effects. Herein, a tumor microenvironment (TME)-activated NIR-II nanotheranostic system (FEAD1) for precise diagnosis and treatment of peritoneal metastases is presented. FEAD1 was fabricated by self-assembling the peptide Fmoc-His, mercaptopropionic-functionalized Ag2S quantum dots (MPA-Ag2S QDs), the chemodrug doxorubicin (DOX), and NIR absorber A1094 into nanoparticles. We show that in healthy tissue, FEAD1 exists in an NIR-II fluorescence “off” state, because of Ag2S QDs-A1094 interactions, while DOX remains in stealth mode. Upon delivery of FEAD1 to the tumor, the acidic TME triggers its disassembly through breakage of the Fmoc-His metal coordination and DOX hydrophobic interactions. Release of A1094 switches on Ag2S fluorescence, illuminating the tumor, accompanied by burst release of DOX within the tumor tissue, thereby achieving precise tumor theranostics. This TME-activated theranostic strategy holds great promise for future clinical applications. |
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| Keywords: | Koordinative Assemblierung Nanotheranostik NIR-II Tumormetastase Tumormikroumgebung |
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