Salicylaldimine-bridged dinuclear cyclopalladated complexes: Synthesis,characterization and BSA binding studies |
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| Authors: | Yan Gao Saimeng Zhang Xiaoguang Li Shuyao Jiang Yajing Yang Xiaohong Chang |
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| Affiliation: | 1. Liaoning Provincial Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials, College of chemistry, Liaoning University, Shenyang, 110036 China;2. College of Life and Health Sciences, Northeastern University, Shenyang, 110819 China |
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| Abstract: | Salicylaldimine-bridged dinuclear cyclopalladated complexes were synthesized by the reactions of cyclopalladated chloro dimers [Pd{(4-R)C6H3CH=N-C6H3–2,6-i-Pr2}(μ-Cl)]2 (R = H; OMe) with salen-based bridging ligands. The complexes were characterized by FTIR, NMR spectroscopy, elemental analysis and X-ray crystallography. The binding interaction of cyclopalladated complexes to bovine serum albumin (BSA) was investigated by UV–vis, fluorescence and synchronous fluorescence spectroscopy. The experimental results showed that these Pd (II) complexes could bind to BSA with high affinity and quench its intrinsic fluorescence by a static or combined process. Also the interaction of Pd complexes with BSA affected the conformation of the tryptophan and tyrosine residues. |
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| Keywords: | bovine serum albumin cyclopalladated complex Salicylaldimine |
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