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A Prelude to Biogermylene Chemistry** |
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| Authors: | Pritam Mahawar Dr Mishi Kaushal Wasson Dr Mahendra Kumar Sharma Dr Chandan Kumar Jha Dr Goutam Mukherjee Prof?Dr Perumal Vivekanandan Prof?Dr Selvarajan Nagendran |
| Institution: | 1. Department of Chemistry, Indian Institute of Technology Delhi (IIT Delhi), Hauz Khas, New Delhi, 110016 India;2. Kusuma School of Biological Sciences, Indian Institute of Technology Delhi (IIT Delhi), Hauz Khas, New Delhi, 110016 India |
| Abstract: | The biological applications of germylenes remain unrealised owing to their unstable nature. We report the isolation of air-, water-, and culture-medium-stable germylene DPMGeOH ( 3 ; DPM=dipyrromethene ligand) and its potential biological application. Compound 3 exhibits antiproliferative effects comparable to that of cisplatin in human cancer cells. The cytotoxicity of compound 3 on normal epithelial cells is minimal and is similar to that of the currently used anticancer drugs. These findings provide a framework for a plethora of biological studies using germylenes and have important implications for low-valent main-group chemistry. |
| Keywords: | anti-tumor compounds main-group chemistry bioorganometallic chemistry germylenes metallylenes |