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Facile and Efficient Synthesis of (R)‐4‐(Benzyloxy)‐3‐methylbutanenitrile: Toward Developing a Versatile Chiral Building Block |
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| Authors: | Zijie Song Yong Shi Ronghua Jin Jingrong Lin Weisheng Tian |
| Institution: | 1. Laboratory of Resource Chemistry, Shanghai Normal University, 100 Guiling Road, Shanghai 200234, China;2. The Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China |
| Abstract: | A practical synthesis of (R)‐4‐(benzyloxy)‐3‐methylbutanenitrile, a potential chiral building block, from the corresponding α‐keto ester in high yield and large scale was presented. |
| Keywords: | synthetic methods rearrangement (R)‐4‐(benzyloxy)‐3‐methylbutanenitrile chiral building block |