Synthesis and Antimicrobial Activity of New 2,5‐Disubstituted 1,3,4‐Oxadiazoles and 1,2,4‐Triazoles and Their Sugar Derivatives |
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| Authors: | Wael A El‐Sayed Omar M Ali Hend A Hendy Adel A‐H Abdel‐Rahman |
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| Institution: | 1. Department of Photochemistry, National Research Centre, Cairo, Egypt;2. Chemistry Department, Northern Border University, Arar, Saudi Arabia;3. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El‐Koam, Egypt |
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| Abstract: | A series of new 2,5‐disubstituted‐1,3,4‐oxadiazole and 1,2,4‐triazole derivatives were synthesized by heterocyclization of acid hydrazide 1 and thiosemicarbazide derivative 2 . Furthermore, the acyclic C‐nucleoside analogs were prepared by cyclization of their corresponding sugar hydrazones by reaction with acetic anhydride. The antimicrobial activity of the prepared compounds was evaluated and some of the synthesized compounds revealed good activities against fungi. |
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| Keywords: | 1 3 4‐oxadiazoles 1 2 4‐triazoles sugar hydrazones acyclic nucleosides antimicrobial activity |
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