New lignan from the rattan stems of Schisandra chinensis |
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Authors: | Bing-You Yang Zhang-Lin Chen Yan Liu Jiang-Tao Guo |
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Institution: | 1. Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, People’s Republic of China;2. Gui Yang College of Traditional Chinese Medicine, Guiyang, People’s Republic of China |
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Abstract: | A new lignan named schilignan F (1), together with twelve known ones (2–13), were isolated from the rattan stems of Schisandra chinensis. Their chemical structures were elucidated by spectroscopic methods including one and two-dimensional NMR spectra referring to the literatures as well as high-resolution mass spectrometric analysis. All compounds were evaluated for their cytotoxicities against human Hela cancer cell lines in vitro. The results showed that compounds 2, 6 and 8 exhibited weak cytotoxic activity with IC50 values of 30.6, 86.3 and 41.0 μM, and cisplatin showed cytotoxic activity with IC50 value of 27.3 μM. |
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Keywords: | Magnoliaceae lignan Schisandra chinensis natural products cytotoxicity |
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