Two new phenylspirodrimanes from the deep-sea derived fungus Stachybotrys sp. MCCC 3A00409 |
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| Authors: | Xin-hua Ma Wei-min Zheng Kai-hui Sun Xiao-fan Gu Xian-ming Zeng Hai-tao Zhang |
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| Affiliation: | Fujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China |
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| Abstract: | Two new phenylspirodrimanes, stachybotrin H (1) and stachybotrysin H (9) together with eleven known analogues (2–8, 10–13) were isolated from deep-sea derived Stachybotrys sp. MCCC 3A00409. Their structures were determined by extensive NMR data and mass spectroscopic analysis. Compounds 9–12 showed weak cytotoxicity against three human cancer cell lines K562, Hela and HL60 with IC50 in the range of 18.5–52.8 μM. |
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| Keywords: | Deep-sea derived fungus Stachybotrys sp. phenylspirodrimanes cytotoxicity |
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