Three new sesquiterpenes from Ainsliaea glabra |
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| Authors: | Ya-Ping Chen Cui Tong Wen-Quan Lu Yun-Heng Shen |
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| Institution: | 1. Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, China;2. Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China;3. College of Pharmacy, Second Military Medical University, Shanghai, China |
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| Abstract: | Three new sesquiterpenes: 4-acrylic-6-methyl-α-tetralone (1), ainsliaea acid A (2) and ainsliaea acid B (3), together with 8 known compounds (4-11) were isolated from the whole herb of Ainsliaea glabra and their structures were established by means of 1D and 2D NMR spectroscopy and HR-ESIMS. Compounds 1–6 were tested for the inhibition of nuclear factor kappa B (NF-κB) in the 293-NF-κB-luciferase reporter cell line induced by lipopolysaccharide (LPS), and compound 2 was further tested for the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6 and IL-10 in RAW264.7 macrophages induced by LPS. The isolated compound 2 exhibited significant anti-inflammatory activity. |
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| Keywords: | Ainsliaea glabra sesquiterpene anti-inflammatory activity |
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