Lebbeckoside C,a new triterpenoid saponin from the stem barks of Albizia lebbeck inhibits the growth of human glioblastoma cells |
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Authors: | Olivier Placide Noté Joséphine Ngo Mbing Marie-Claude Kilhoffer Dieudonné Emmanuel Pegnyemb Annelise Lobstein |
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Institution: | 1. Faculté de Pharmacie, Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Illkirch Cedex, France;2. Faculté de Sciences, Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Université de Yaoundé, Yaoundé, Cameroon;3. Faculté de Sciences, Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Université de Yaoundé, Yaoundé, Cameroon;4. Faculté de Pharmacie, Chimie-Biologie Intégrative, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Illkirch Cedex, France |
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Abstract: | One new acacic acid-type saponin, named lebbeckoside C (1), was isolated from the stem barks of Albizia lebbeck. Its structure was established on the basis of extensive analysis of 1D and 2D NMR (1H, 13C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence as 3-O-β-d-xylopyranosyl-(l→2)-β-d-fucopyranosyl-(1→6)-β-d-glucopyranosyl(1→2)]-β-d-glucopyranosyl]-21-O-{(2E,6S)-6-O-{4-O-(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-4-O-(2E,6S)-2,6-dimethyl-6-O-(β-d-quinovopyranosyl)octa-2,7-dienoyl]-β-d-quinovopyranosyl}-2,6-dimethylocta-2,7-dienoyl}acacic acid 28 O-β-d-quinovopyranosyl-(l→3)-α-l-arabinofuranosyl-(l→4)]-α-l-rhamnopyranosyl-(l→2)-β-d-glucopyranosyl] ester. The isolated saponin (1) displayed significant cytotoxic activity against the human glioblastoma cell line U-87 MG and TG1 stem-like glioma cells isolated from a patient tumor with IC50 values of 1.69 and 1.44 μM, respectively. |
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Keywords: | Albizia lebbeck mimosaceae triterpenoid saponin cytotoxic activity U-87 MG and TG1 stem-like glioma cells |
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