Flavone glucosides from Artemisia juncea |
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| Authors: | Bakhodir S Okhundedaev Markus Bacher Rimma F Mukhamatkhanova Ildar J Shamyanov Gokhan Zengin Stefan Böhmdorfer |
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| Institution: | 1. Institute of the Chemistry of Plant Substances of the Academy Sciences of Uzbekistan, Tashkent, Uzbekistan;2. Division of Chemistry of Renewables, Department of Chemistry, University of Natural Resources and Life Sciences, Vienna (BOKU University), Tulln, Austria;3. Department of Biology, Faculty of Science, University of Selcuk, Konya, Turkey |
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| Abstract: | A new flavone glucoside, 4′,5-dihydroxy-3′,5′,6-trimethoxyflavone-7-O-β-D-glucoside was obtained from aerial parts of Artemisia juncea, together with the known flavone eupatilin (5,7-dihydroxy-3′,4′,6-trimethoxyflavone). The compounds were comprehensively analytically characterized by IR, UV, NMR and HR-MS, and their chemical structures ascertained. The EtOAc fraction of A. juncea showed the strongest DPPH radical scavenging ability as well as reducing power (in CUPRAC and FRAP assays) and phosphomolybdenum activity. This fraction also exhibited the strongest inhibitory effects on tyrosinase. Additionally, the best antidiabetic effects were observed for eupatilin and the CHCl3 fraction. |
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| Keywords: | Artemisia juncea flavones flavonoid 4′ 5-dihydroxy-3′ 5′ 6-trimethoxyflavone-7-O-β-D-glucoside eupatilin antioxidant enzyme inhibitor |
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