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| Mn-SOD模拟物及其在神经退行性疾病中的药用前景 | |
| 引用本文： | 丁隽,林骏,陈兰明,郭子建. Mn-SOD模拟物及其在神经退行性疾病中的药用前景[J]. 无机化学学报, 2001, 17(3): 305-309 |
| 作者姓名： | 丁隽 林骏 陈兰明 郭子建 |
| 作者单位： | 南京大学,南京大学生物医药技术国家重点实验室, |
| 基金项目： | 国家自然科学基金资助项目(No.29925102)。 |
| 摘 要： | 本文通过分析神经退行性疾病与线粒体机能障碍、自由基损伤的关系，主要讨论了Mn-SOD模拟物作为自由基清除剂对活性氧化合物的清除机理、药用优势，并总结了近年来有关Mn-SOD模拟物在神经退行性疾病防治方面的研究近况及潜在应用前景。 |
| 关 键 词： | 超氧化物歧化酶 SOD模拟物 锰配合物 线粘体机能障碍 防治 无机化合物 自由基清除剂 神经退行性疾病 |
| 收稿时间： | 2001-02-14 |
| 修稿时间： | 2001-02-14 |
Mn-SOD Mimics and their Potential Application in the Protection of Neurodegenerative Diseases |
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| DING Jun,LIN Jun,CHEN Lan-Ming and GUO Zi-Jian. Mn-SOD Mimics and their Potential Application in the Protection of Neurodegenerative Diseases[J]. Chinese Journal of Inorganic Chemistry, 2001, 17(3): 305-309 | |
| Authors: | DING Jun LIN Jun CHEN Lan-Ming GUO Zi-Jian |
| Affiliation: | State Key Laboratory of Coordination Chemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093,State Key Laboratory of Coordination Chemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093,State Key Laboratory of Coordination Chemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093 and State Key Laboratory of Coordination Chemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093 |
| Abstract: | This article has reviewed the latest advances in neurodegenerative diseases, focusing on their relationship with mitochondrial dysfunction and free radical damage. The latest research advances on the functional mimics of Mn-SOD as promising therapeutic agents to neurodegenerative diseases are summarized. The Mn-SOD mimics possess several advantages over native enzymes on stability, efficacy and toxicity. Progress in the field is heavily dependent on the understanding of the chemical bases of the diseases and the discovery of novel protective and therapeutic agents. |
| Keywords: | Mn-SOD mimics free radical scavenger neurodegenerative diseases |
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