Synthesis,Crystal Structures and Anticancer Activity of the New Chiral Mono‐ and Dinuclear Palladium(II) Complexes derived from (S)‐(‐)‐(1‐phenylethylimino)benzylphenylketone |
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Authors: | Ma Angeles Pelez Teresa Ramírez Marcos Martínez Pankaj Sharma Cecilio lvarez Ren Gutirrez |
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Institution: | Ma. Angeles Peláez,Teresa Ramírez,Marcos Martínez,Pankaj Sharma,Cecilio Álvarez,René Gutiérrez |
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Abstract: | The enantiopure ketoimine of benzil – the ( S )‐(‐)‐(1‐phenylethylimino)benzyl phenyl ketone ( 1 ) obtained under microwave irradiation in solvent‐free conditions – reacts with Na2PdCl4] to give the new chiral mono‐ and dinuclear Pd‐complexes 2 and 3 , which have been partly characterized by IR, 1H and 13C NMR spectroscopies along with MS‐FAB+ spectrometry. The crystal and molecular structures of both complexes has been fully confirmed by single‐crystal X‐ray studies. On the other hand, investigations in vitro of 2 and 3 have displayed growth inhibition against different classes of cancer: leukemia (K‐562 CML), colon cancer (HCT‐15), cancer breast (MCF‐7), central nervous system (U‐251 Glio) and prostate cancer (PC‐3) cell lines. |
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Keywords: | Palladium Anticancer activity Chiral complexes Enantiopure α ‐ketoimines |
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