| 含甲硫基和肟醚基的N-甲氧基氨基甲酸酯类化合物的合成及生物活性研究 |
| |
| 引用本文： | 刘卫东,兰世林,兰支利,王晓光.含甲硫基和肟醚基的N-甲氧基氨基甲酸酯类化合物的合成及生物活性研究[J].有机化学,2006,26(8):1115-1119. |
| |
| 作者姓名： | 刘卫东 兰世林 兰支利 王晓光 |
| |
| 作者单位： | 1. 湖南化工研究院,国家农药创制工程技术研究中心,长沙,410007
2. 湖南师范大学化学化工学院,长沙,410081 |
| |
| 基金项目： | 国家十五科技攻关(No.2004BA308A22)，湖南省杰出青年科学基金(No.04JJ1009)资助项目. |
| |
| 摘 要： | 为了寻找高效、低毒的农药, 设计合成了一系列新的含甲硫基和肟醚基的N-甲氧基氨基甲酸酯类化合物5a～5q, 其结构经IR, 1H NMR, LC/MS和元素分析确认. 生物活性测定表明, 部分化合物在50 mg/L下对稻瘟病菌(Pyricularia oryzae)、灰霉病菌(Botrytis cinerea)、水稻纹枯病菌(Rhizoctonia solani)和小麦白粉病菌(Blumeria griminis)有很好的抑菌活性.
|
| 关 键 词： | 甲硫基肟醚 N-甲氧基氨基甲酸酯 合成 杀菌活性 |
| 收稿时间： | 09 29 2005 12:00AM |
| 修稿时间： | 02 21 2006 12:00AM |
Synthesis and Bioactivity of N-Methoxylcarbamates Contain-ing Methylthio and Oxime Ether Group |
| |
| LIU, Wei-Dong,LAN, Shi-Lin,LAN, Zhi-Li,WANG, Xiao-Guang.Synthesis and Bioactivity of N-Methoxylcarbamates Contain-ing Methylthio and Oxime Ether Group[J].Chinese Journal of Organic Chemistry,2006,26(8):1115-1119. |
| |
| Authors: | LIU Wei-Dong LAN Shi-Lin LAN Zhi-Li WANG Xiao-Guang |
| |
| Institution: | 1.Hunan Research Institute of Chemical Industry, National Engineering Research Center of Agrochemicals, Changsha 410007;2. College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081 |
| |
| Abstract: | In an attempt to find novel compounds with high activity and low toxicity, a series of novel N-methoxylcarbamates containing methylthio and oxime ethers 5a-5q were designed and synthesized according to bioisoster principle. Their structures were confirmed by ^1H NMR, IR, LC/MS spectra and elemental analysis. The prelimilary biological activity tests show that some compounds possess fungicidal activities against Pyricularia oryzae, Botrytis cinerea, Rhizoctonia solani and Blumeria griminis. |
| |
| Keywords: | methylthio oxime ether N-methoxylcarbamate synthesis fungicidal activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
| 点击此处可从《有机化学》下载免费的PDF全文 |
|
