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Directed Evolution of a Soluble Human IL-17A Receptor for the Inhibition of Psoriasis Plaque Formation in a Mouse Model

Authors:	Marianna Zaretsky Revital Etzyoni Joel Kaye Liora Sklair-Tavron Amir Aharoni

Institution:	1. Department of Life Sciences, Ben-Gurion University of the Negev, Be’er Sheva 84105, Israel;2. National Institute for Biotechnology in the Negev (NIBN), Ben-Gurion University of the Negev, Be’er Sheva 84105, Israel;3. Innovative Ventures Division, Teva Pharmaceutical Industries, P.O. Box 8077, Netanya 42504, Israel;4. Pharmacology Department, Teva Pharmaceutical Industries, P.O. Box 8077, Netanya 42504, Israel

Abstract:	Download : Download high-res image (276KB) Download : Download full-size image Highlights? IL-17 is involved in many inflammatory diseases ? Directed evolution of IL-17A receptor results in improved IL-17A affinity ? The engineered receptors efficiently inhibit IL-17A induced cytokine secretion ? Engineered receptor promotes the recovery of psoriasis plaques in mouse model

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