1. Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, 3000, Belgium;2. Institute of Systems and Synthetic Biology, University of Evry-Val-d’Essonne, Evry, F-91030, France
Abstract:
Highlights? A highly modified nucleotide as substrate for polymerases ? The reversibility of the polymerase reaction at the template level ? Synthesis of a nucleoside with two anomeric centers