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A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase

Authors:	Lai Hong Wong Asier Unciti-Broceta Michaela Spitzer Rachel White Mike Tyers Lea Harrington

Institution:	1. Wellcome Trust Centre for Cell Biology, King’s Buildings, University of Edinburgh, Mayfield Road, Edinburgh, EH9 3JR, UK;2. Edinburgh Cancer Research UK Centre, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK;3. Faculty of Medicine, University of Montreal, Institute for Research in Immunology and Cancer, Chemin de Polytechnique, Montreal, Quebec, H3T 1J4 Canada

Abstract:	Download : Download high-res image (173KB) Download : Download full-size image Highlights? Growth arrest induced by human telomerase in yeast is chemically reversible ? Readout is sensitive to telomerase catalytic activity and telomere recruitment ? Three cell-permeable compounds also inhibit purified human telomerase ? Yeast can be successfully used to screen for human telomerase inhibitors

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